28/04/2025
Nospamin Drops contain Homatropine Methyl Bromide as an active ingredient.
The drug homatropine methylbromide is a member of the class of drugs known as antimuscarinics and is a quaternary ammonium muscarinic acetylcholine receptor antagonist. The muscarinic acetylcholine receptor mediates various cellular responses, including modulation of potassium channels by G proteins, dissolution of phosphoinositides, and inhibition of adenylate cyclase.
In addition to smooth muscles that respond to acetylcholine but lack cholinergic innervation, homatropine methylbromide also inhibits the muscarinic effects of acetylcholine on structures innervated by postganglionic cholinergic nerves.
The autonomic effector cells of the smooth skeletal muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands all contain these postganglionic receptor sites. Anticholinergics may have a mildly relaxing effect on the bile ducts and gallbladder, depending on the dose, and they may decrease the gastrointestinal system’s motility and secretory activity as well as the tone of the ureter and urinary bladder.
Homatropine is used to treat intestine issues as well as stomach or duodenal ulcers. It may also be used to prevent nausea, vomiting, and motion sickness. Nospamin Drops work by blocking the chemical acetylcholine. The blood-brain barrier is not crossed by it.
Side-effects.
The following is a list of possible side-effects that may occur from all the constituting ingredients of Nospamin Drops.
Blurred vision.
Burning.
Eye itching.
Urinary retention is rare.
Interactions with Nospamin Drops
Nospamin drops interact with the following list of drugs;
Antacids.
Carbonic anhydrase inhibitors.
Citrates.
Sodium bicarbonate.
DOSE
Dosage for infants:
The dose should be according to body weight; 1mg per kg body weight 3 to 4 times daily.
For up to 3 months, administer 2 to 4 drops, 3 to 4 times daily.
For 3 to 6 months, administer 4 to 6 drops, 3 to 4 times daily.